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. 2019 Apr 2;9:5496. doi: 10.1038/s41598-019-41896-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Requirement of N782 for proliferation of keratinocytes. (a) Illustration of KDM2A and N782. C, P, N, and LRR indicate CXXC, PHD, NLS, and leucine repeat region, respectively. (b) Expression of N782 and KDM2A in 7-day cultivated keratinocytes at different densities of 3T3-J2. Blue and red indicate N782 and KDM2A, respectively, throughout Fig. 1. p = 0.0095. (c) Keratinocyte proliferation under the same conditions. (d) Proportional relationship of N782 to the cell proliferation rate. Mean ± SD. (e) Keratinocyte proliferation transduced with N782, KDM2A, and the empty vector (green). p = 0.0043 (N782 vs. the control) and 0.0249 (KDM2A vs the control). (f) Expression of N782 and KDM2A in the presence and absence of 3T3-J2 in EpiLife medium. p = 0.0128. (g) Expression of N782 and KDM2A in hESC. *In Fig. 1 shows a significant difference (P < 0.05) by either ANOVA or t-test. n = 3 for (b–f), 2 for (e), and 6 for (g).