Table 1.

Summary of the TF combinations that include Ascl1 or Ngn2 to directly reprogram somatic or pluripotent cells into specific iN subtypes.

Factors	Source	iN main subtype	Reference
Ascl1, Brn2, Myt1l	Fibroblasts	GABA/Gluta	Vierbuchen et al., 2010; Pfisterer et al., 2011
Ascl1, Myt1l, NeuroD2, miR-9/9∗, miR-124	Fibroblasts	GABA/Gluta	Yoo et al., 2011
Ascl1	Fibroblasts	GABA/Gluta	Chanda et al., 2014
Ascl1, Brn2, Myt1l	Fibroblasts	GABA/Gluta	Pereira et al., 2014
Ascl1, Brn2, Myt1l, Neurod1	Fibroblasts	Gluta	Pang et al., 2011
Ascl1, Sox2, FoxG1, Dlx5, Lhx6	Fibroblasts	GABA	Colasante et al., 2015
Ascl1, Brn2, Myt1l,Ngn2, Lhx3,Isl1, Hb9 (NeuroD1)	Fibroblasts	Motor	Son et al., 2011
Ascl1, Brn2, Myt1l, Lmx1a, Foxa2	Fibroblasts	Dopaminergic	Pfisterer et al., 2011
Ascl1, Nurr1, Lmx1a	Fibroblasts	Dopaminergic	Caiazzo et al., 2011
Ascl1, Pitx3	Fibroblasts	Dopaminergic	Kim et al., 2011
Ascl1, Brn2, Myt1l, Lmx1a, Lmx1b, FoxA2, Otx2	Fibroblasts	Dopaminergic	Torper et al., 2013
Ascl1, Dlx2	Astrocytes	GABA	Heinrich et al., 2010
Ascl1	Astrocytes	GABA	Chouchane et al., 2017
Ascl1, Nurr1, Lmx1b	Astrocytes	Dopaminergic	Addis et al., 2011
Ascl1	ESCs	GABA/Gluta	Chanda et al., 2014
Ascl1, Sox2, FoxG1, Dlx5, Lhx6	iPSCs	GABA	Colasante et al., 2015
Ascl1, Dlx2	ESCs, iPSCs	GABA	Yang et al., 2017
Ngn2, Ascl1	Fibroblasts	Gluta	Ladewig et al., 2012
Ngn2, Sox11, Isl1, Lhx3	Fibroblasts	Motor	Liu et al., 2015
Ngn2, Brn3a	Fibroblasts	Sensory	Blanchard et al., 2015
Ngn2, (Sox11)	Fibroblasts	Cholinergic	Liu et al., 2013; Smith et al., 2016
Ngn2	Astrocytes	Gluta	Heinrich et al., 2010; Chouchane et al., 2017
Ngn2, Bcl2	Astrocytes	Gluta	Gascón et al., 2016
Ngn2	Cerebellar Astrocytes	GABA	Chouchane et al., 2017
Ngn2	NPC	Gluta	Ho et al., 2016; Orellana et al., 2016
Ngn2	iPS, ESCs	Gluta	Zhang et al., 2013; Busskamp et al., 2014; Rubio et al., 2016