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. 2019 Apr 2;10:1501. doi: 10.1038/s41467-019-09493-3

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Fig. 4 — Ligand-induced conformational changes. In-line probing of a 5′-AlexaFluor 647-labeled BsPreQ₁-RS RNA and b 5′-AlexaFluor 647-labeled TtPreQ₁-RS RNA after treatment with 1 at increasing concentrations or a DMSO control in the absence (–) or presence (+) of 1 mm MgCl₂. Treatment with PreQ₁ at a concentration of 10 μm is used as a positive control. OH and T1 are a partial alkaline hydrolysis ladder and ribonuclease T1 digestion, respectively. Arrows designate nucleotide positions where the cleavage efficiency was significantly altered by compound treatment (blue) or preQ₁ treatment (red)