Table 2.
A summary table of significant effects and interactions from a repeated measures MANCOVA analysis performed using SPSS V24 using 4 repeated measures at times baseline, post-treatments and FU1 and FU2. Between subject groupings were Active_Sham and LPCS_SPCS. Dependent variables were RPQ3, RPQ13, MADRS and EVestG (AP-area). Tests in order are: Multivariate tests, Mauchly’s test of sphericity, Tests of Within-subject effects, Univariate tests, and Pairwise Comparisons.
| Multivariate Tests | Wilkes-Lambda | Hypothesis | Error | Sig. | Partial eta | Observed | ||
|---|---|---|---|---|---|---|---|---|
| Effect (a) | Value | F | df | df | squared | power (c) | ||
| Between all Subjects | Sham_Active * LPCS_SPCS | 0.304 | 6.305 (b) | 4 | 11 | 0.007 | 0.696 | 0.918 |
| Between LPCS Subjects | Sham_Active | 0.159 | 6.635 (b) | 4 | 5 | 0.031 | 0.841 | 0.746 |
| Within all Subjects | time * LPCS_SPCS | 0.005 | 46.343 (b) | 12 | 3 | 0.005 | 0.995 | 0.999 |
| a All = Design: Intercept + Sham_Active + LPCS_SPCS + Sham_Active * LPCS_SPCS Within Subjects Design: time | ||||||||
| b Exact statistic, c Computed using p = 0.05 | ||||||||
| Mauchly’s Test of Sphericity | ||||||||
| Within Subjects Effect (population) (a) | Mauchly’s W | Approx. Chi-Square | df | Sig. | Greenhouse -Geisser | Epsilon (d) Huynh-Feldt | Lower -bound | |
| time (SPCS only) | MADRS | 0.055 | 13.663 | 5 | 0.02 | 0.031 | 0.841 | 0.746 |
| time (Sham only) | MADRS | 0.121 | 12.089 | 5 | 0.036 | 0.031 | 0.841 | 0.746 |
| Tests the null hypothesis that the error covariance matrix of the orthonormalized transformed dependent variables is proportional to an identity matrix. | ||||||||
| d May be used to adjust the degrees of freedom for the averaged tests of significance. Corrected tests are displayed in the Within-Subjects Effects table. | ||||||||
| Tests of Within-Subjects Effects | ||||||||
| Multivariate (a,e) | Wilkes-Lambda Value | F | Hypothesis df | Error df | Sig. | partial eta squared | observed power (f) | |
| population | 0.378 | 3.833 | 12 | 103.476 | 0 | 0.277 | 0.993 | |
| all | time | 0.151 | 3.476 | 12 | 39.978 | 0.001 | 0.468 | 0.962 |
| SPCS only | time | 0.204 | 3.285 | 12 | 47.915 | 0.002 | 0.411 | 0.961 |
| Active only | time | 0.395 | 3.63 | 12 | 103.476 | 0 | 0.266 | 0.99 |
| all | time * LPCS_SPCS | 0.227 | 3.002 | 12 | 47.915 | 0.003 | 0.39 | 0.941 |
| Active only | time * LPCS_SPCS | 0.378 | 3.833 | 12 | 103.476 | 0 | 0.277 | 0.993 |
| e Tests are based on average variables, f Computed alpha = 0.05. | ||||||||
| Univariate Tests, Sphericity tested | ||||||||
| Source (population) | Measure | Type III Sum of Squares | df | Mean Square | F | Sig. | partial eta squared | observed power (f) |
| time | RPQ3 | 66.421 | 3 | 22.14 | 8.454 | 0 | 0.377 | 0.989 |
| time | RPQ13 | 554.644 | 3 | 184.881 | 6.581 | 0.001 | 0.32 | 0.959 |
| time | EVestG | 741.369 | 3 | 247.123 | 8.894 | 0 | 0.388 | 0.992 |
| time (SPCS only) | RPQ3 | 119.898 | 3 | 39.966 | 10.98 | 0 | 0.647 | 0.995 |
| time (SPCS only) | RPQ13 | 883.586 | 3 | 294.529 | 6.404 | 0.004 | 0.516 | 0.924 |
| time (SPCS only) | MADRS (g) | 461.25 | 1.87 | 246.475 | 7.862 | 0.008 | 0.567 | 0.867 |
| time (SPCS only) | EVestG | 1034.201 | 3 | 344.734 | 9.491 | 0.001 | 0.613 | 0.988 |
| time (LPCS only) | RPQ3 | 38.353 | 3 | 12.784 | 6.987 | 0.002 | 0.5 | 0.952 |
| time (Active only) | RPQ3 | 28.754 | 3 | 9.585 | 2.812 | 0.064 | 0.287 | 0.59 |
| time (Active only) | RPQ13 | 596.562 | 3 | 198.854 | 9.581 | 0 | 0.578 | 0.99 |
| time (Active only) | EVestG | 688.983 | 3 | 229.661 | 9.218 | 0 | 0.568 | 0.988 |
| time * LPCS_SPCS | RPQ3 | 67.199 | 3 | 22.4 | 8.553 | 0 | 0.379 | 0.989 |
| time * LPCS_SPCS | RPQ13 | 443.046 | 3 | 147.682 | 5.257 | 0.004 | 0.273 | 0.904 |
| time * LPCS_SPCS | MADRS | 351.006 | 3 | 117.002 | 4.855 | 0.005 | 0.258 | 0.878 |
| time * LPCS_SPCS | EVestG | 539.952 | 3 | 179.984 | 6.477 | 0.001 | 0.316 | 0.956 |
| time * LPCS_SPCS (Active only) | RPQ3 | 48.254 | 3 | 16.085 | 4.72 | 0.011 | 0.403 | 0.831 |
| time * LPCS_SPCS (Active only) | RPQ13 | 562.368 | 3 | 187.456 | 9.032 | 0 | 0.563 | 0.986 |
| time * LPCS_SPCS (Active only) | MADRS | 303.633 | 3 | 101.211 | 4.584 | 0.013 | 0.396 | 0.819 |
| time * LPCS_SPCS (Active only) | EVestG | 550.843 | 3 | 183.614 | 7.37 | 0.001 | 0.513 | 0.962 |
| g Greenhouse Geisser test applied rather than Sphericity assumed | ||||||||
| Pairwise Comparisons | ||||||||
| p, baseline to post | p, baseline to FU1 | p, baseline to FU2 | ||||||
| time | RPQ3 | 0.008 | 0.001 | 0.001 | ||||
| RPQ13 | 0.004 | 0.010 | ||||||
| MADRS | 0.003 | |||||||
| EVestG | 0.006 | 0.026 | 0.001 | |||||