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Chimeric furin, WNV and DENV-2 NS2B-NS3 protease inhibitors of the formula.
 | ||||||
|---|---|---|---|---|---|---|
| No. | P3 | MS (calc./found) (M + H)+ | HPLC tR (min) | Ki (μM) (WNV) | Ki (μM) (DENV) | Ki (pM) (furin) |
| 45 | Val | 749.46/375.91a | 19.7 | 5.70 | 77.3 | 7.60 |
| 46 | Tle | 763.47/764.39 | 20.8 | 6.45 | 83.1 | 5.50 |
| 47 | Arg | 806.49/404.31a | 16.2 | 0.65 | 11.6 | 56.9 |
| 48 | Lys | 778.48/390.2a | 16.2 | 0.82 | 1.22 | 44.8 |
MS found (M + 2 H)2+/2.
