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. 2017 Jul 20;32(1):960–967. doi: 10.1080/14756366.2017.1344980

Figure 4.

Figure 4.

(A) HPLC chromatogram of a standard 1.0 mM equimolar mixture of compounds NTZ-1471 (a, ret. time 7.52 min), NTZ-1441 (b, ret. time 8.25 min) and NTZ-1091 (c, ret. time 9.17 min) in methanol (MeOH). Conditions: 40% methanol mobile phase, 10 μL sample injection volume, and 250 μL/min flow rate. (B) Mean solubility of the compounds in pure water and 50% methanol measured by LC/ESI-MS method. (C) Distribution of BBB mean permeability of standard drugs and subclass II compounds measured in the PAMPA assay.