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. 2017 Jul 20;32(1):960–967. doi: 10.1080/14756366.2017.1344980

Table 3.

Solubility and PAMPA-BBB data for selected compounds.

	Solubility in water^a		Solubility in 50% methanol^a		PAMPA-BBB^a,^b
Compound	μg/mL	μM	μg/mL	mM	P_e (×10⁻⁶ cm/s)	−logP_e
NTZ-1091	5.62 ± 0.17	17.6 ± 0.5	156 ± 19	0.49 ± 0.06	117.5 ± 6.4	3.91
NTZ-1441	42.1 ± 2.3	136 ± 5	609 ± 49	2.04 ± 0.18	144.2 ± 3.4	3.84
NTZ-1471	61.6 ± 9.6	215 ± 33	610 ± 26	2.12 ± 0.09	148.1 ± 2.4	3.83

^a

The values are the mean ± SD (n ≥ 3).

^b

PAMPA blood-brain barrier (BBB) values were determined under stirring at the pH value of the Prisma HT buffer (Pion).