Table 1.
Functional comparison of CAR-T cells manufactured using open versus closed production platform
| IFN-γ (pg/mL ± SEM) | ||
|---|---|---|
| Cella | Openb | Closedc |
| None | 133.8 ± 66.8 | 42.0 ± 13.6 |
| Toledo | 15169 ± 5494.3 | 27026.2 ± 16501.6 |
| NALM6 | 12773.4 ± 4629.7 | 24241.2 ± 12432.8 |
| CEM | 115.6 ± 54.0 | 21.0 ± 13.7 |
a
CD19+ cell lines (Toledo, NALM6); CD19− (CEM).
b
Open: cells transduced by spinoculation.
c
Closed: cells transduced using closed production process.
CAR-T cells, chimeric antigen receptor T cells; IFN-γ, interferon gamma; SEM, standard error of the mean.