Table 1.
Statistical analysis of the parasitic and histopathological effects of eugenol and praziquantel on Schistosoma mansoni-infected mice
| Control group | Eugenol | Praziquantel | ||
|---|---|---|---|---|
| Mean worm burden | Male | 3.2±1.9 | 3±1.4 | 0.0±0.0 |
| Female | 0±0 | 0±0 | 0.0±0.0 | |
| Couple | 4.7±1.03 | 3±1.7 | 0.0±0.0 | |
| Total | 7.8±2.3 | 6.3±2.4 | 0.0±0.0 | |
| Total worm burden reduction (%) | 19.2 | 100 | ||
| Number of ova/gram, mean ± SEM | Intestine | 8,929±1,614.3 | 7,886.6±504.2 | 354.7±64.9 |
| Reduction of ova count in tissues (%) | 11.7* | 96* | ||
| Egg developmental stages, mean ± SEM | Immature eggs | 50±3.6 | 51±1.7 | 0±0 |
| Mature eggs | 42±2.5 | 43±1 | 12±2 | |
| Dead ova | 6.3±1.2 | 6±1 | 88±2 | |
| GD (µm) | Granuloma in liver tissue | 273.25±14.81 | 203.47±8.08 | 239.77±6.58 |
| Reduction in GD (%) | 25.54* | 12.26 | ||
| Granuloma number | Granuloma in liver tissue | 21.38±0.62 | 13.76±0.26 | 9.79±0.58 |
| Reduction in granuloma number (%) | 35.65* | 54.21* |
Note:
*
Significant result (P<0.05).
Abbreviations: GD, granuloma diameter; SEM, standard error of the mean.