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. 2019 Mar 28;14:621–630. doi: 10.2147/CIA.S193765

Figure 2.

Figure 2

High level of melatonin affected the level of autophagy-related proteins and microRNAs in AF cells of patients with DD. (A and B) Show the mRNA and protein levels of ATG5, ATG7, ATG12, ULK1, and Beclin 1 in AF cells of patients with DD and treated with melatonin of 50 µmol/L. (C) The mRNA levels of miR-20a-5p, miR-96-5p, miR-106a-5p, miR-210-3p, and miR-375 in AF cells of patients with DD and treated with melatonin of 50 µmol/L.

Notes: *P<0.05 vs control; **P<0.01 vs control, ***P<0.001 vs control.

Abbreviations: AF, annulus fibrosus; DD, disc degeneration; M50, melatonin of 50 µmol/L.