Table 5.

Factors associated with reoperation with mastectomy for invasive BC: multivariate analysis

Re-excision vs mastectomy Invasive		P-value	OR	95% CI
				Inferior	Superior
Histology	Ductal		1
	Lobular	<0.0001	1.820	1.369	2.418
	Others	0.348	1.175	0.839	1.646
LVI	No		1
	Yes	0.066	1.247	0.985	1.578
Periods	1995–2004		1
	2005–2010	0.552	0.917	0.688	1.221
	>2010	<0.0001	0.429	0.328	0.562
Focality	Unifocal		1
	Bifocal	<0.0001	2.955	2.161	4.041
	Multifocal	<0.0001	9.334	5.497	15.85
Grade	1		1
	2	0.024	1.336	1.039	1.719
	3	0.039	1.393	1.016	1.909
DCIS component	DCIS – IT and peripheric	0.393	0.911	0.736	1.128
Positive margins	Focal		1
	Diffuse	<0.0001	2.508	1.880	3.346
Age, years	≤40		1
	41–50	0.835	0.963	0.673	1.377
	51–74	0.002	0.602	0.433	0.836
	≥75	0.309	0.768	0.462	1.276
Global size, mm	<20		1
	20–49.9	<0.0001	2.372	1.856	3.032
	≥50	<0.0001	18.16	13.32	24.75
Phenotype	ER+ Her2–		1
	ER+ Her2+	0.048	1.453	1.003	2.105
	ER– Her2+	0.007	2.085	1.228	3.540
	ER– Her2–	0.20	1.294	0.873	1.919

Abbreviations: BC, breast cancer; LVI, lymphovascular peritumoral invasion; DCIS, ductal carcinoma in situ; IT, intratumoral.