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. 2019 Mar 29;14:631–642. doi: 10.2147/CIA.S200109

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© 2019 Sumirtanurdin et al. This work is published and licensed by Dove Medical Press Limited

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Possible mechanism of polymorphisms in ChAT and CHRNA7 affecting ChEI cognitive response.

Notes: ChEI increases the levels of acetylcholine, which binds the alpha-7 nAChR encoded by CHRNA7. The effect of polymorphisms in ChAT with AChEI therapy response is associated with the synthesis capacity of the remaining cholinergic neurons to favor the response to AChEIs. The polymorphism effect of CHRNA7 on the therapeutic response may be through 1) modulation of the release of the neurotransmitters in presynaptic neurons, 2) memory enhancement by modulation of cholinergic neurotransmission, 3) neuroprotection through the alpha-7 nAChR, 4) regulation enhancement of apha-7 nAChR by ChEI, and 5) positive allosteric modulation of galantamine-mediated at the apha-7 nAChR.

Abbreviations: ChAT, choline acetyltransferase; ChEI, cholinesterase inhibitor; SNP, single nucleotide polymorphism.