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. 2019 Mar 20;10:254. doi: 10.3389/fphar.2019.00254

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Copyright © 2019 Dang, Li, Sun, Wang, Lin, Zhang, Dai and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of the combined effects of the B. chinense-S. baicalensis herbal pair in Alcoholic Liver Injury. Alcoholic Liver Injury was used to research the characteristics of B. chinense- S. baicalensis, which is controlled by B. chinense and S. baicalensis, and their main active ingredients baicalin and saikosaponin. The biochemical indicators and histology indicated that B. chinense-S. baicalensis presented the best efficacy, which could be further illustrated by global, local, and symbiotic metabolic analysis. Finally, metallomic analysis was employed to uncover the distribution changes of selenium which, unlike other metal elements, was significantly increased by B. chinense-S. baicalensis in liver tissue to demonstrate multiple benefits such as anti-oxidative stress and hepatoprotective effect, to relieve drug pressure.