Table 2.

Contributions of the single herbs and their active ingredients to the disturbed pathways of B. chinense-S. baicalensis herbal pair.

Source	Pathway	Constituents
		Scutellaria baicalensis	Bupleurum chinense	Baicalin	Saikosaponin	Mixture
Serum	Biosynthesis of unsaturated fatty acids	✓	✓	✓	✓	✓
Liver	ABC transporters		✓	✓	✓	✓
	Aminoacyl-tRNA biosynthesis		✓	✓	✓	✓
	Pantothenate and CoA biosynthesis		✓	✓	✓	✓
	Propanoate metabolism		✓	✓	✓	✓
	Pyrimidine metabolism					✓
	Valine, leucine and isoleucine biosynthesis		✓	✓	✓	✓
	Valine, leucine and isoleucine degradation				✓	✓
Feces	ABC transporters	✓	✓	✓	✓	✓
	Aminoacyl-tRNA biosynthesis	✓	✓	✓	✓	✓
	Cysteine and methionine metabolism	✓	✓	✓	✓	✓
	Pantothenate and CoA biosynthesis	✓	✓	✓	✓	✓
	Phenylalanine metabolism	✓	✓	✓	✓	✓
	Phenylalanine, tyrosine and tryptophan biosynthesis	✓	✓	✓	✓	✓
	Propanoate metabolism	✓	✓	✓		✓
	Valine, leucine and isoleucine biosynthesis	✓	✓	✓	✓	✓