Squamous cell carcinoma (SCC), skin, cat. Figure 3. Case 2. (a) Region of SCC with increasing epithelial disorganization and invasion into superficial dermis. HE. (b and c) Strong, dot-like signals are evident within invasive SCC. In situ hybridization (ISH) for FcaPV-2 E6/E7. Figure 4. Case 3. (a) Neoplastic squamous epithelial cells surrounding a vessel within the deep dermis. HE. (b and c) Strong, dot-like signals are evident within the invasive SCC cells. ISH for FcaPV-2 E6/E7. Figure 5. SCC, pinnae (an area of ultraviolet light exposure), case 14. (a) Region of SCC with epithelial disorganization and invasion into superficial dermis. HE. (b) Hybridization signals are absent from the normal epidermis and SCC. ISH for FcaPV-2 E6/E7.