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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Trends Pharmacol Sci. 2019 Mar 7;40(4):267–277. doi: 10.1016/j.tips.2019.02.002

Figure 3. Multifunctional activity of ABHD6.

Figure 3.

A. Rise in intracellular calcium concentration activates diacylglycerol lipase (DGL) that cleaves diacylglycerol (DAG) into 2-AG. ABHD6 hydrolyzes 2-AG into arachidonic acid (AA) and glycerol (not shown). Thus, ABHD6 controls the activity-dependent 2-AG accumulation and eventual activation of cannabinoid receptors CB1R and CB2R and GABAA receptors. B. ABHD6 controls the hydrolysis of monoacylglycerols (MAG) into fatty acids (FA). MAG accumulation might module the activity of unknown receptors targets and/or modify lipid membrane composition. C. ABHD6 acts as a chaperone to traffic AMPA receptors to the plasma membrane.