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. 2019 Apr 2;9:5495. doi: 10.1038/s41598-019-41980-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Principal Component Analysis of matrices of average interaction strength of A2aR. Trajectories of A2aR coupled to Mini-Gs or to the α5 helix in the absence of NECA were grouped together, both being closer to the NECA bound form than to the free receptor. This indicates that α5 could maintain the pattern of contacts of the Mini-Gs coupled receptor.