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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Mol Cancer Res. 2018 Dec 14;17(3):783–793. doi: 10.1158/1541-7786.MCR-18-0530

Figure 2. Endothelial Ccr2 is required for lung metastasis.

Figure 2

A) Spontaneous lung metastasis in C57BL/6, Ccr2fl/fl, Ccr2ecKO, and Ccr2-/- mice 28 days after subcutaneous injection of LLC1.1 cells. **; p<0.01; ns = not significant. B) Representative images of lungs from mice analyzed in panel A. C) Representative images of pulmonary metastasis stained with anti-CD31 (vasculature) and anti-F4/80 (macrophages) antibodies. Proliferating cells (Ki67 staining) and apoptotic cells (cleaved Caspase 3 staining; cl-Casp3) were evaluated. The edge of a metastatic lesion is presented. The histological analysis of metastatic foci only was performed. Bar = 50 μm.