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. Author manuscript; available in PMC: 2019 Apr 2.
Published in final edited form as: Biomaterials. 2018 Sep 17;185:240–275. doi: 10.1016/j.biomaterials.2018.09.028

Figure 1.

Figure 1

Interscale representation of bone. (a) A macroscopic-to-microscopic view of cancellous and cortical bone. Bone marrow lies in the cavities of cancellous bone, which are lined by the endosteum structure. Tightly packed osteons integrate cortical tissue, which is covered by the periosteum membrane. Osteons are formed by Harvasian canals, which contain blood vessels and nerve tissue, surrounded by concentric lamellae that show thicknesses of circa 3 μm. Osteocytes reside in the osteon inside lacuna structures. (b) Bone tissue is constituted at the nanometric scale by collagen fibers that comprise assembled collagen triple helix structures that give rise to the collagen fibril, with a characteristic periodic spacing of 67 nm, and gaps of 40 nm where the mineral component of bone is located.