Table 3.
RSS enzymes involved in biosynthesis of organic cofactors
| L1 Subgroup Name and (#) | Family | Cofactor | Type of Lifea |
|---|---|---|---|
| anaerobic coproporphyrinogen-III oxidase (2) | heme degradation proteins (HutW/ChuW) | Heme (degradation) | B |
| oxygen-independent coproporphyrinogen-III oxidase 1 (HemN) | Heme (biosynthesis) | BPVI | |
| oxygen-independent coproporphyrinogen-III oxidase 2 (HemZ) | B | ||
| B12-binding domain (5) | anaerobic magnesium-protoporphyrin-IX monomethyl ester cyclase | Bacteriochlorophyll/anaerobicly synthesized chlorophyll | B |
| BATS domain containing (6) | 2-iminoacetate synthase (ThiH) | Thiamine | ABPI |
| [Fe] hydrogenase maturase (HydG) | [Fe] Hydrogenase metallocofactor assembly | BPI | |
| biotin synthase | Biotin | ABPVI | |
| HMD cofactor maturase (HmdB) | 5,10-Methenyltetrahydromethanopterin hydrogenase cofactor | AB | |
| [FeFe] hydrogenase maturase (HydE) | [FeFe] hydrogenase metallocofactor assembly | BPI | |
| F420, menaquinone cofactor biosynthesis (9) | ((2,3,4,5-tetrahydroxypentyl)amino)dihydropyrimidine-2,4-dione synthase (CofH) | 8-hydroxy-5-deazaflavin (Coenzyme F420) | ABP |
| 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (CofG) | ABPV | ||
| aminofutalosine synthase (mqnE) | Menaquinone via futalosine (two steps along the same pathway) | AB | |
| cyclic dehypoxanthine futalosine synthase () | ABPV | ||
| FeMo cofactor biosynthesis protein (10) | FeMo cofactor biosynthesis protein (nifB) | FeMo cofactor | AB |
| lipoyl synthase (11) | lipoyl synthase | Lipoyl | ABPVI |
| SPASM/twitch domain containing (17) | coenzyme PQQ synthesis protein E (PqqE) | Pyrroloquinoline quinone (PQQ) | B |
| cyclic pyranopterin phosphate synthase (MoaA) | Molybdenum cofactor | ABPVI | |
| alternative heme biosynthesis C (AhbC) | Heme B (two steps along the same pathway) | AB | |
| alternative heme biosynthesis D (AhbD) | |||
| C-terminal tyrosine decarboxylase (MftC) | Mycofactocin peptide maturase | B | |
| heme D1 biosynthesis (NirJ) | Heme d1 | B | |
| tungsten cofactor oxidoreducase radical SAM maturase | Tungsten containing cofactors | AB |
a
Type of life: B: bacteria, P: plants, V: vertebrates, I: invertebrates, A: archaea