Table 2.
Echocardiographic Responses to a Cryo-Myocardial Infarction.
| Variablea | Groupb | Prec | 4 Wks | 8 Wks | 12 Wks | ANOVA-RMd | |
|---|---|---|---|---|---|---|---|
| HR (bpm) |
MI Sham |
220 ± 7 219 ± 7 |
245 ± 8 221 ± 7 |
225 ± 11 222 ± 9 |
226 ± 9 213 ± 13 |
0.66 | |
| EDD (mm) |
MI Sham |
16.7 ± 0.2 17.0 ± 0.3 |
21.1 ± 0.6* 17.3 + 07 |
23.0 ± 0.8* 17.2 ± 0.7 |
23.3 ± 0.9* 17.3 ± 0.5 |
0.001 | |
| ESD (mm) |
MI Sham |
11.0 ± 0.2 11.2 ± 0.2 |
16.9 ± 0.5* 11.7 ± 0.7 |
18.5 ± 0.8* 11.8 ± 0.7 |
19.0 ± 0.7* 11.5 ± 0.6 |
0.001 | |
| IVSd (mm) |
MI Sham |
2.38 ± 0.07 2.54 ± 0.05 |
2.63 ± 0.10 2.67 ± 0.12 |
2.6 ± 0.10 2.97 ± 0.12 |
2.76 ± 0.14 2.64 ± 0.12 |
0.15 | |
| IVSs (mm) |
MI Sham |
3.61 ± 0.06 3.91 ± 0.09 |
3.80 ± 0.13 4.08 ± 0.20 |
3.61 ± 0.12* 4.46 ± 0.32 |
3.86 ± 0.19 3.89 ± 0.07 |
0.03 | |
| LVFWd (mm) |
MI Sham |
2.54 ± 0.07 2.68 ± 0.07 |
1.92 ± 0.12* 2.75 ± 0.14 |
1.88 ± 0.11* 3.05 ± 0.21 |
1.95 ± 0.14* 2.99 ± 0.22 |
0.03 | |
| LVFWs (mm) |
MI Sham |
4.03 ± 0.10 4.33 ± 0.13 |
2.50 ± 0.24* 4.31 ± 0.16 |
2.40 ± 0.21* 4.35 ± 0.28 |
2.23 ± 0.17* 4.07 ± 0.13 |
0.003 | |
| FS (%) |
MI Sham |
34.4 ± 0.8 34.2 ± 0.6 |
20.2 ± 0.8* 32.7 ± 1.8 |
18.7 ± 0.6* 31.7 ± 1.7 |
19.1 ± 0.7* 34.0 ± 1.4 |
0.001 | |
| Vcf (circ/s) |
MI Sham |
3.13 ± 0.09 2.99 ± 0.08 |
1.79 ± 0.07* 3.03 ± 0.15 |
1.74 ± 0.09* 2.95 ± 0.24 |
1.62 ± 0.04* 3.02 ± 0.17 |
0.001 | |
| EF (%) |
MI Sham |
63 ± 2 59 ± 1 |
38 ± 1* 57 ± 2 |
37 ± 2* 56 ± 2 |
35 ± 1* 59 ± 2 |
0.001 |
HR= Heart rate, beats perm in.; EDD=End Diastolic Dimension; ESD= End Systolic Dimension; IVSd = Interventricular septum thickness in dsstole; IVSs= Interventricular septum thickness in systole; LVFWd = Left ventricular free wallthickness in dastole; LVFWs = Left ventricular free wall thickness h systole; FS = Fractional Shortening; Vcf = Circumferential fiber shortening; EF = Ejection Fraction.
MI = Myocardial infarction group, n= 10; Sham = Sham operated group, n=6.
Data presented as Mean ± SEM for pre-surgery (Pre) and 4, 8 and 12 weeks post-op;
Analysis of Variance with repeated measures (ANOVA – RM) was used to compare the two groups overtime. Post-hoc comparisons were performed using Sidak’s multiple comparison test.
p< .001 vs Sham. Graph Pad/Prism 6 Statistical Software.