Fig. 1.

Scheme of the subcellular localization of enzymes in TIA pathway of Catharanthus roseus. Dashed arrows indicate multiple steps. Open arrow represents cross-flow between plastidial MEP and cytosolic/peroxisomal mevalonate pathway. ER endoplasmatic reticulum, DMAPP dimethylallyl diphosphate, IPP isopentenyl diphosphate, IDI IPP isomerase, GPP geranyl diphosphate, GPPS GPP synthase, FPP farnesyl diphosphate, FPPS FPP synthase, GES geraniol synthase, G8O geraniol 8-oxidase, 8-HGO 8-hydroxygeraniol oxidoreductase, IS iridoid synthase, IO iridoid oxidase, 7DLGT 7-deoxyloganetic acid glucosyl transferase, 7DLH 7-deoxyloganic acid hydroxylase, LAMT loganic acid O-methyltransferase, SLS secologanin synthase, STR strictosidine synthase, SGD strictosidine β-d-glucosidase, T16H tabersonine 16-hydroxylase, OMT 16-hydoxytabersonine 16-O-methyltransferase, NMT N-methyltransferase, D4H desacetoxyvindoline 4-hydroxylase, DAT deacetylvindoline 4-O-acetyltransferase, PRX peroxidase, PRX1 peroxidase 1, TDC tryptophan decarboxylase