Table 4. Uni- and multi-variate analysis of factors associated with the magnitude of changes in fibrosis-4 index (FIB-4).

Baseline variables	Univariate			Multivariate
	β	SE	p-value	β	SE	p-value
Age (years)	0.167	0.096	0.0856	0.062	0.015	<0.0001
Sex (Male: Female)	-1.464	1.724	0.3978
HCC (Yes: No)	0.273	3.187	0.9318
BMI (kg/m2)	0.085	0.237	0.7208
Prothrombin time (INR)	0.125	0.654	0.8485
AST (U/L)	-0.091	0.010	<0.0001
ALT (U/L)	0.0020	0.0023	0.3743
Total bilirubin (mg/dl)	0.958	2.457	0.6975
Platelet (1000/mm3)	0.037	0.016	0.0204	-0.022	0.003	<0.0001
Alpha-fetoprotein (ng/mL)	-0.005	0.029	0.8622
HCVRNA (IU/mL, log)	-1.259	1.273	0.3248
FIB-4 index	-0.906	0.020	<0.0001	-0.947	0.015	<0.0001
Baseline-LS (kPa)	-0.024	0.070	0.7267
Baseline-CAP (dB/m)	-0.000	0.025	0.9927
Triglyceride (mg/dl)	0.009	0.014	0.5190
Total cholesterol (mg/dl)	-0.003	0.026	0.9043

HCC, hepatocellular carcinoma; BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; FIB-4, fibrosis-4; CAP, controlled attenuation parameter