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. 2019 Apr 2;14(4):e0214462. doi: 10.1371/journal.pone.0214462

Fig 1. Schematic representation of C1 metabolism. DNA polymorphisms determined in lung cancer case-control study population from northern Poland.

Fig 1

C1, methyl group; CBS, cystathionine-beta-synthase; DHFR, dihydrofolate reductase; HCOOH, formate; MTHFD1, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase (soluble); MTHFR, 5,10-methylenetetrahydrofolate reductase; MTR, methionine synthase; MTRR, methionine synthase reductase; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; SLC19A1, solute carrier family 19 (reduced folate transporter), member 1; SHMT1, serine hydroxymethyltransferase 1 (soluble); TCN2, transcobalamin; THF, tetrahydrofolate; TYMS, thymidylate synthase; 5-CH3-THF, 5-methyltetrahydrofolate; 5-CHO-THF, 5-formyltetrahydrofolate; 5,10-CH2 = THF, 5,10- methylenetetrahydrofolate; 5,10 = CH-THF, 5,10- methenyltetrahydrofolate; 10-CHO-THF, 10-formyltetrahydrofolate.