Table 3. Odds ratios of lung cancer occurrence in relation to genotypes in the C1 metabolism genes, in study population from northern Poland.
| Polymorphism | Genotype | Lung cancer cases (% of genotype carriers) |
Controls (% of genotype carriers) |
OR (95% CI), P |
|---|---|---|---|---|
| rs1801133 MTHFR c.665C>T |
CC | 65 (49) | 158 (40) | 1 (Ref) |
| CT | 55 (42) | 199 (50) | 0.66 (0.43–1.01), P = 0.056 | |
| TT | 12 (9) | 39 (10) | 0.75 (0.37–1.51), P = 0.423 | |
| P for trend = 0.120 | ||||
| TvsCC(Ref) | 0.68 (0.45–1.01), P = 0.057 | |||
| TTvsC(Ref) | 0.92 (0.47–1.80), P = 0.801 | |||
| rs1801131 MTHFR c.1286A>C |
AA | 69 (52) | 193 (49) | 1 (Ref) |
| AC | 49 (37) | 169 (43) | 0.80 (0.53–1.23), P = 0.314 | |
| CC | 14 (11) | 34 (9) | 1.16 (0.59–2.29), P = 0.665 | |
| P for trend = 0.818 | ||||
| CvsAA(Ref) | 0.87 (0.59–1.29), P = 0.482 | |||
| CCvsA(Ref) | 1.27 (0.65–2.45), P = 0.484 | |||
| CBS c.844_845ins68 | DD | 110 (83) | 343 (87) | 1 (Ref) |
| I allele | 22 (17) | 53 (13) | 1.32 (0.75–2.31), P = 0.338 | |
| rs1979277 SHMT1 c.1420C>T |
CC | 53 (40) | 164 (41) | 1 (Ref) |
| CT | 61 (46) | 186 (47) | 1.02 (0.66–1.57), P = 0.935 | |
| TT | 18 (14) | 46 (12) | 1.22 (0.64–2.31), P = 0.546 | |
| P for trend = 0.618 | ||||
| TvsCC(Ref) | 1.06 (0.70–1.59), P = 0.794 | |||
| TTvsC(Ref) | 1.21 (0.67–2.18), P = 0.535 | |||
| rs2236225 MTHFD1 c.1958G>A |
GG | 39 (30) | 131 (33) | 1 (Ref) |
| GA | 63 (48) | 182 (46) | 1.15 (0.74–1.80), P = 0.530 | |
| AA | 30 (23) | 83 (21) | 1.21 (0.70–2.09), P = 0.496 | |
| P for trend = 0.470 | ||||
| AvsGG(Ref) | 1.17 (0.77–1.78), P = 0.463 | |||
| AAvsG(Ref) | 1.11 (0.69–1.78), P = 0.669 | |||
| rs1801394 MTRR c.66A>G |
GG | 50 (38) | 119 (30) | 1 (Ref) |
| GA | 58 (44) | 190 (48) | 1.09 (0.63–1.87), P = 0.768 | |
| AA | 24 (18) | 87 (22) | 1.50 (0.87–2.60), P = 0.148 | |
| P for trend = 0.115 | ||||
| AvsGG(Ref) | 0.70 (0.47–1.06), P = 0.095 | |||
| AAvsG(Ref) | 0.79 (0.48–1.30), P = 0.359 | |||
| rs1805087 MTR c.2756A>G |
AA | 91 (69) | 245 (62) | 1 (Ref) |
| AG | 36 (27) | 133 (34) | 0.73 (0.47–1.13), P = 0.162 | |
| GG | 5 (4) | 18 (5) | 0.75 (0.27–2.10), P = 0.587 | |
| P for trend = 0.178 | ||||
| GvsAA(Ref) | 0.73 (0.48–1.12), P = 0.148 | |||
| GGvsA(Ref) | 0.83 (0.30–2.28), P = 0.710 | |||
| rs202243265 rs11280056 rs16430 TYMS 3'UTR ins/del |
II | 67 (51) | 179 (45) | 1 (Ref) |
| ID | 61 (46) | 184 (46) | 0.88 (0.59–1.33), P = 0.547 | |
| DD | 4 (3) | 33 (8) | 0.33 (0.11–0.96), P = 0.041 | |
| P for trend = 0.079 | ||||
| 3*DvsII(Ref) | 0.80 (0.53–1.19), P = 0.261 | |||
| 3*DDvsI(Ref) | 0.35 (0.12–1.00), P = 0.050 | |||
| TYMS 5'UTR 2R/3R | 2R/2R | 32 (24) | 72 (18) | 1 (Ref) |
| 2R/3R | 66 (50) | 205 (52) | 0.716 (0.43–1.18), P = 0.189 | |
| 3R/3R | 34 (26) | 119 (30) | 0.62 (0.34–1.12), P = 0.112 | |
| P for trend = 0.120 | ||||
| 5' 3Rvs2R2R(Ref) | 0.69 (0.42–1.11), P = 0.125 | |||
| 5' 3R3R vs2R(Ref) | 0.80 (0.51–1.26), P = 0.333 | |||
| DHFR c.86+60_78ins22 | II | 36 (27) | 119 (30) | 1 (Ref) |
| ID | 72 (55) | 198 (50) | 1.22 (0.76–1.95), P = 0.414 | |
| DD | 24 (18) | 79 (20) | 1.01 (0.56–1.80), P = 0.985 | |
| P for trend = 0.886 | ||||
| DvsII(Ref) | 1.15 (0.74–1.79), P = 0.541 | |||
| DDvsI(Ref) | 0.89 (0.54–1.48), P = 0.659 | |||
| rs1801198 TCN2 c.776C>G |
CC | 39 (30) | 125 (32) | 1 (Ref) |
| CG | 64 (48) | 183 (46) | 1.12 (0.71–1.75), P = 0.634 | |
| GG | 29 (22) | 88 (22) | 1.05 (0.61–1.82), P = 0.850 | |
| P for trend = 0.810 | ||||
| GvsCC(Ref) | 1.10 (0.72–1.67), P = 0.670 | |||
| GGvsC(Ref) | 0.99 (0.62–1.58), P = 0.952 | |||
| rs61510559 SLC19A1 c.80G>A |
GG | 35 (27) | 115 (29) | 1 (Ref) |
| GA | 68 (52) | 191 (48) | 1.17 (0.73–1.87), P = 0.514 | |
| AA | 29 (22) | 90 (23) | 1.06 (0.60–1.88), P = 0.834 | |
| P for trend = 0.803 | ||||
| AvsGG(Ref) | 1.14 (0.72–1.78), P = 0.574 | |||
| AAvsG(Ref) | 0.96 (0.60–1.54), P = 0.857 | |||
| rs61510559 SLC19A1 c.80G>A Women |
GG | 11 (18) | 57 (31) | 1 (Ref) |
| GA | 31 (51) | 95 (52) | 1.72 (0.80–3.73), P = 0.168 | |
| AA | 19 (31) | 31 (17) | 3.14 (1.32–7.46), P = 0.010 | |
| P for trend = 0.009 | ||||
| AvsGG (Ref) | 2.08 (1.00–4.31), P = 0.050 | |||
| AAvsG (Ref) | 2.16 (1.12–4.17), P = 0.022 | |||
| rs61510559 SLC19A1 c.80G>A Men |
GG | 24 (34) | 58 (27) | 1 (Ref) |
| GA | 37 (52) | 96 (45) | 0.90 (0.49–1.66), P = 0.740 | |
| AA | 10 (14) | 59 (28) | 0.39 (0.17–0.91), P = 0.030 | |
| P for trend = 0.040 | ||||
| AvsGG (Ref) | 0.73 (0.40–1.31), P = 0.284 | |||
| AAvsG (Ref) | 0.42 (0.20–0.88), P = 0.022 |