Fig 1. Schematic illustration of the experimental design.

For the evaluation of plaque development, inflammation, ROS formation, and endothelial function ApoE^-/- mice were used after 8 weeks of intraperitoneal application of NaSCN (200 μg every other day) or vehicle (DMSO). For the assessment of neointima formation wild-type mice were subjected to carotid artery wire injury, treated with NaSCN (200 μg every other day) or vehicle for 14 days, and then analyzed.