Table 3. Contrasts, lsmean, SE and significanes of ELISA for the 4 different groups (control-1, control-2, OA-model-1, OA-model-2) and 3 different time points (week 1, week 2, week 3) for MMP1, MMP3, MMP 13, ADAMTS5 and IL-6.

Significant values are highlighted in bold font.

	contrast	lsmean	SE	p-value
MMP1	OA-model-1 vs control-1	-0.43 vs -0.45	0.08	0.99
	OA-model-2 vs control-2	-0.32 vs -0.32	0.08	1.00
	control-1 vs control-2	-0.45 vs -0.32	0.08	0.40
	OA-model-1 vs OA-model-2	-0.43 vs -0.32	0.08	0.48
	week1 vs week2	-0.01 vs -0.51	0.07	<0.0001
	week2 vs week3	-0.51 vs -0.63	0.08	0.23
	week1 vs week3	-0.01 vs -0.63	0.08	<0.0001
MMP3	OA-model-1 vs control-1	2.12 vs 2.82	0.28	0.09
	OA-model-2 vs control-2	2.51 vs 3.10	0.30	0.23
	control-1 vs control-2	2.82 vs 3.10	0.30	0.79
	OA-model-1 vs OA-model-2	2.12 vs 2.51	0.27	0.48
	week1 vs week2	3.16 vs 2.70	0.25	0.18
	week2 vs week3	2.70 vs 2.05	0.25	0.03
	week1 vs week3	3.16 vs 2.05	0.26	0.0005
MMP13	OA-model-1 vs control-1	-0.20 vs 0.14	0.22	0.39
	OA-model-2 vs control-2	-0.11 vs -0.02	0.27	0.97
	control-1 vs control-2	0.14 vs -0.02	0.26	0.94
	OA-model-1 vs OA-model-2	0.20 vs 0.11	0.23	0.98
	week1 vs week2	0.18 vs -0.12	0.19	0.31
	week2 vs week3	-0.12 vs -0.18	0.21	0.95
	week1 vs week3	0.18 vs -0.18	0.21	0.20
ADAMTS5	OA-model-1 vs control-1	1.93 vs 1.95	0.02	0.68
	OA-model-2 vs control-2	1.89 vs 1.92	0.02	0.54
	control-1 vs control-2	1.95 vs 1.92	0.02	0.30
	OA-model-1 vs OA-model-2	1.93 vs 1.89	0.02	0.20
	week1 vs week2	1.93 vs 1.93	0.21	0.99
	week2 vs week3	1.93 vs 1.91	0.21	0.62
	week1 vs week3	1.93 vs 1.91	0.21	0.64
IL-6	OA-model-1 vs control-1	0.99 vs 1.67	0.17	0.002
	OA-model-2 vs control-2	1.11 vs 1.15	0.18	0.99
	control-1 vs control-2	1.67 vs 1.15	0.18	0.03
	OA-model-1 vs OA-model-2	0.99 vs 1.11	0.17	0.91
	week1 vs week2	1.36 vs 1.13	0.14	0.28
	week2 vs week3	1.13 vs 1.20	0.15	0.89
	week1 vs week3	1.36 vs 1.20	0.15	0.56