Table 3:
Changes in CVLT-II and D-KEFS Color Word Interference Test Scores over Six Months in Estrogen-Replaced vs. Non-replaced Groupsa,b
| EST+(n=29) | EST-(n=19) | Effect size (95% CI) | P | P* | EST PHYSIOL (n=13) | EST ORAL (n=16) | Effect size EST PHYSIOL vs. EST- (95% CI) | Effect size EST PHYSIOL vs. ORAL (95% CI) | Effect size EST Oral vs. EST-(95% CI) | P | P* | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CVLT-II | ||||||||||||
| Immediate recall (Trial 1) | 13.79±2.55 | 3.95±2.77 | 9.85 (2.05,17.64) | 0.01 | 0.02 | 19.58±3.17 | 11.25±3.31 | 15.64* (4.70,26.57) | 8.33 (−2.99,19.65) | 7.30 (−2.76,17.36) | 0.005 | 0.04 |
| Immediate recall (Trial 5) | 3.62±2.13 | 5.26±2.15 | −1.64 (−8.00,4.72) | 0.61 | 0.24 | 6.25±2.55 | 3.13±3.02 | 0.99 (−8.18,10.15) | 3.13 (−6.37,12.62) | 2.14 (−6.30,10.57) | 0.70 | 0.47 |
| Immediate recall (Trial1–5) | 11.75±1.69 | 5.84±1.13 | 5.91 (1.35,10.47) | 0.01 | 0.10 | 14.00±2.38 | 10.06±2.34 | 8.16** (1.41,14.90) | 3.94 (−3.05,10.92) | 4.22 (−1.98,10.43) | 0.02 | 0.21 |
| Immediate recall (Trial B) | 3.97±1.69 | −1.05±1.93 | 5.02 (−0.24,10.27) | 0.06 | 0.01 | 5.38±2.23 | 2.81±2.50 | 6.44 (−1.31,14.19) | 2.57 (−5.47,10.61) | 3.87 (−3.44,11.17) | 0.13 | 0.04 |
| D-KEFS | ||||||||||||
| Inhibition Error Analysis | 2.19±0.79 | −0.11±1.96 | 2.30 (−1.48,6.09) | 0.23 | 0.22 | 4.92±1.65 | 0.23±0.51 | 5.03 (−0.55,10.62) | 4.69 (−1.33,10.71) | 0.34 (−5.25,5.93) | 0.08 | 0.47 |
| Inhibition/Switching Completion Time | 4.46±0.99 | 1.08±1.40 | 3.38 (−0.16,6.92) | 0.05 | 0.06 | 3.90±1.07 | 3.92±1.34 | 2.85 (−1.54,7.24) | 0.02 (−4.69,4.73) | 2.82 (−1.89,7.53) | 0.22 | 0.14 |
| Inhibition/Switching Error Analysis | 0.39±1.09 | −2.33 ±.1.79 | 2.72 (−1.32,6.77) | 0.18 | 0.07 | −0.70±1.50 | 1.23±1.56 | 1.63 (−4.27,7.54) | 1.93 (−3.87,7.73) | 3.56 (−1.95,9.08) | 0.30 | 0.19 |
a
Table 3 shows the changes in the CVLT-II and D-KEFS scores at 6 months by treatment groups. Student t test and ANOVA were used for initial comparisons (unadjusted p values reported).
b
Boldface indicates statistical significance.
C
Adjusted for baseline score.
*
p=0.003,
**
p=0.01 after Tukey Kramer’s adjustment for multiple comparisons.
Abbreviations: CVLT-II: California Verbal Learning Test, Edition II, D-KEFS: Delis Kaplan Executive Function System, EST-: No estrogen replacement, EST+: Estrogen replacement, EST ORAL: Oral estrogen groups and EST PHYSIOL: Transdermal estrogen