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Binding site structures (x-ray). (a) AChBP with ACh (top; PDB ID: 3WIP; Olsen et al., 2014) or nicotine (bottom; PDB ID: 1UW6; Celie et al., 2004). Dashed lines are H-bonds; red dot is a structural water. (b) α4β2 AChR with nicotine (top; PDB ID: 5KXI; Morales-Perez et al., 2016) or docked ACh (bottom). In both structures, before equilibration the agonist tail points toward the complementary subunit, but after equilibration it is flipped only in α4β2 (Table 1).
