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. 2019 Jan 11;151(4):452–464. doi: 10.1085/jgp.201812212

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Figure 3. — Binding site structural parameters. Pocket volume was calculated as that of the pyramid formed by joining the centers of the five aromatic rings (front face, white). Distances are between the agonist’s principal nitrogen (Fig. 1 b) and the pocket center (d_x) or the five ring centers (d₉₃, d₁₄₉, d_190, d₁₉₈, and d₅₅), and between loop C and the complementary subunit backbone (d_loopC). Angle Θ_a is the agonist’s orientation. Not shown: angles Θ_s (pocket skew), Θ_W (between indole planes), Θ_p (between pyramid and pore axes), and density of water in the pocket. PDB ID: 3WIP; residue numbers are for endplate AChRs.