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. 2019 Jan 22;151(4):518–531. doi: 10.1085/jgp.201812270

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© 2019 Chen et al.

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Figure 2. — I-V curves of WT TMEM16A and mutants. I-V curves in the presence of (A) 20 μM and (B) 20 mM [Ca²⁺]_i. Symmetrical 140 mM [Cl⁻]. In both A and B, averaged I-V curves of WT_16A, K584Q_16A, K584R_16A, and K584E_16A are depicted on top, while the averaged RI values (means ± SEM, n = 3–36) of the WT_16A and various mutants are shown at the bottom. **, P < 0.005 by Student’s t test compared with WT_16A. n.s., not significant.