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. 2019 Jan 22;151(4):518–531. doi: 10.1085/jgp.201812270

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© 2019 Chen et al.

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Figure 4. — [Ca²⁺]_i-dependent activation of WT_16F. Symmetrical 140 mM [Cl⁻]. (A) Representative traces obtained at +40 mV (blue) and −40 mV (orange) showing the three-pulse protocol. Dashed lines are zero current level. Numbers and horizontal bars on top of the traces indicate the application of indicated [Ca²⁺]_i (in micromolar). Notice the rapid current rundown of TMEM16F. (B) [Ca²⁺]_i-dependent activation curve of TMEM16F. All current was normalized to that obtained with 900 µM [Ca²⁺]_i. Data points were the average of 3–12 independent measurements (mean ± SEM). The fitted values of K_1/2 and Hill coefficient (h) are shown next to the fitted curve.