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. 2019 Jan 22;151(4):518–531. doi: 10.1085/jgp.201812270

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© 2019 Chen et al.

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Figure 6. — Mutation of Q559_16F alters the Ca²⁺-dependent rundown of TMEM16F. WT_16F (black) and various mutants of Q559_16F were activated by 2 mM [Ca²⁺]_i at +40 mV in symmetrical 140 mM [Cl⁻]. Dashed lines are zero current level. Black horizontal line segments above the traces indicate the 10-s application of 2 mM [Ca²⁺]_i. To evaluate the degree of Ca²⁺-induced rundown, the current measured at the end of the 10-s [Ca²⁺]_i exposure (I_10s) was divided by the maximal current (I_max) in the same 10-s recording in [Ca²⁺]_i. Bar graph shows the averaged values of I_10s/I_max, indicating the nondesensitized current fraction after exposure to 2 mM [Ca²⁺]_i for 10 s (n = 3–8).