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. 2019 Jan 22;151(4):518–531. doi: 10.1085/jgp.201812270

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© 2019 Chen et al.

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Figure 8. — Comparing ion selectivity between WT_16F and Q559W_16F. All recordings were with 1 mM [Ca²⁺]_i and 140 mM [NaCl]_o. (A) Representative I-V curves of WT_16F and Q559W_16F in 140 mM (black), 84 mM (orange), and 42 mM (blue) [NaCl]_i. Insets show the expansion of the I-V curves near the zero current level. (B) Values of E_rev plotted against [NaCl]_i in Cl⁻ experiments of reducing [NaCl]_i with and without the replaced (NMDG)₂SO₄. Green line depicts a perfect Nernstian relation for Cl⁻. Orange squares were the mean E_rev of WT_16A in the same ionic conditions reproduced from Jeng et al. (2016). (C) Representative I-V curves of WT_16F and Q559W_16F in 140 mM [NaCl]_i (black), [NaI]_i (orange), and [NaSCN]_i (blue). (D) Comparing bi-ionic potentials between WT_16F and Q559W_16F. The values of E_rev show no statistically significant difference between WT_16F and Q559W_16F.