Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 11;151(4):567–577. doi: 10.1085/jgp.201812152

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Ivarsson et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 7. — Pharmacologically destabilizing RYR1 causes signaling promoting mitochondrial biogenesis. (A) Boxplots of relative mRNA expression of PGC1α1, MEF2c, TFAM, and COX5B shown relative to HPRT expression in NaCl-, rapamycin- and SLF-injected mice, values were normalized to mean expression of NaCl, which was set to 1.0 (n = 6). (B) Original Western blots (top) and boxplot of relative expression (below) for PGC1α1 with actin as loading control; data presented as relative to the average NaCl, which was set to 100% (n = 6). (C) Original Western blots (top) and boxplot of relative T412 phosphorylation per total S6K1 (below) show no significant effects of Rapamycin or SLF on S6K1; data presented relative to average NaCl which was set to 100% . *, P < 0.05; **, P < 0.01; ***, P < 0.001 Rap or SLF vs. controls (NaCl) with one-way ANOVA. Box plots show median, quartiles, and min/max.