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. 2019 Jan 11;151(4):567–577. doi: 10.1085/jgp.201812152

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© 2019 Ivarsson et al.

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Figure 8. — Prolonged pharmacological destabilization of RYR1 increases mouse oxidative capacity and endurance exercise performance. (A) Citrate synthase activity in tibialis anterior muscles of NaCl-, rapamycin-, and SLF-injected mice and 3-wk runners (n = 13, 9, 6, and 7, respectively). (B) Boxplot of mouse endurances in a treadmill test expressed as the speed of the last completed 2-min interval of sequentially increased speed in four groups of animals: NaCl, rapamycin, and SLF injected and 3 wk runners (3 wk; n = 20 control vs. 10 in each of the other groups). *, P < 0.05; **, P < 0.01; ***, P < 0.001 Rap, SLF, or 3 wk vs. controls (NaCl) with one-way ANOVA. Box plots show median, quartiles, and min/max.