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. 2019 Feb 19;151(4):417–434. doi: 10.1085/jgp.201812298

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© 2019 Anantharam and Kreutzberger

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Figure 7. — Patch-clamp electrophysiology enables real-time detection of granule fusion in mast cells. (A) A sketch of the exocytotic fusion pore that has resulted from fusion. Superimposed on the cartoon is the equivalent circuit. R_c and C_c, resistance and capacitance of the cell membrane; R_g and C_g, resistance and capacitance of the granule membrane; R_p, resistance of the fusion pore; and R_s, series resistance of the patch electrode. Taken from Zimmerberg et al. (1987), A is reprinted with permission from the Proceedings of the National Academy of Sciences of the United States of America. (B) Capacitance, C, and conductance, G_ac, of a mast cell granule as it undergoes exocytosis. Taken from Spruce et al. (1990), B is reprinted with permission from Neuron. (C) Hypothetical sequence of events during exocytosis. The “flicker” between conducting and nonconducting states in the trace in B may arise from transitions between b and c in the model. Based on Breckenridge and Almers (1987), C is reprinted with permission from the Proceedings of the National Academy of Sciences of the United States of America.