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. 2019 Mar 12;43(5):1979–1990. doi: 10.3892/ijmm.2019.4132

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PEDF reduces Na⁺ concentration and glycolytic activation in cardiomyocyte undergoing OGD. (A) Na⁺ concentration, (B) ATP concentration, (C) Na⁺-K⁺ ATPase activity, (D) lactic acid concentration, (E) extracellular acidification rate, and (F) mRNA and (G) protein expression levels of aquaporin were measured in neonatal cardiomyocytes. Cells were divided into the Normal, Normal + PEDF, OGD and OGD + PEDF groups (n=6). ^*P<0.05 and ^**P<0.01 and ^***P<0.001, vs. Normal group; ^#P<0.05 and ^##P<0.01, vs. OGD group. OGD, oxygen-glucose deprivation; PEDF, pigment epithelium derived factor; ECAR, extracellular acidification rate.