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. 2019 Mar 12;43(5):1979–1990. doi: 10.3892/ijmm.2019.4132

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of PEDF on OGD-induced cardiomyocyte edema and injury are associated with decreases in glycolytic activation. (A) Na⁺ concentration, (B) lactic acid concentration, (C) extracellular acidification rate, (D) protein expression of cleaved caspase-3, and (E) cell viability and (F) cell volume were measured in neonatal cardiomyocytes. Cells were divided into the OGD, OGD + PEDF, OGD + PEDF + FDP, OGD + PEDF + DMSO groups (n=6). ^*P<0.05 and ^**P<0.01, vs. OGD group; ^#P<0.05 and ^##P<0.01, vs. OGD + PEDF group. OGD, oxygen-glucose deprivation; PEDF, pigment epithelium derived factor; FDP, fructose-1, 6-diphosphate; RIP3, receptor-interacting protein 3; ECAR, extracellular acidification rate.