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. 2019 Mar 12;43(5):1979–1990. doi: 10.3892/ijmm.2019.4132

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PEDF inhibits cardiomyocyte edema and injury in OGD/R. (A) Cell volume, (B) protein expression of cleaved caspase-3 and RIP3, and (C) cell viability were measured in neonatal cardiomyocytes. Cells were divided into the OGD, OGD + PEDF, OGD/R and OGD/R + PEDF groups (n=6). ^*P<0.05 and ^**P<0.01, vs. OGD control group; ^#P<0.05 and ^##P<0.01, vs. OGD/R control group. (D) CSAs in the I 0.5 h, I0.5 h + PEDF-LVs, I 0.5 h/R2 h and I 0.5 h/R 2 h + PEDF-LVs groups; the results are presented as the mean CSA of 50 random cells (n=6). ^**P<0.01, vs. I group; ^#P<0.05, vs. I 0.5 h/R 2 h group. (E) Transmission electron microscopy of cardiomyocytes (original magnification, ×11,000). OGD, oxygen-glucose deprivation; I, ischemia; R, reperfusion; PEDF, pigment epithelium derived factor; CSA, cross-sectional area; LV, lentivirus; RIP3, receptor-interacting protein 3.