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. 2019 Mar 12;43(5):1979–1990. doi: 10.3892/ijmm.2019.4132

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PEDF decreases the expression of AQP1 in cardiomyocytes during OGD/R. (A) Na⁺ concentration, (B) ATP concentration, (C) Na⁺-K⁺ ATPase activity, (D) lactic acid concentration, (E) extracellular acidification rate, and (F) mRNA and (G) protein expression of AQP1 were measured in neonatal cardiomyocytes. Cells were divided into the Normal, OGD, OGD/R and OGD/R + PEDF groups (n=6). ^*P<0.05 and ^**P<0.01 and ^***P<0.001, vs. Normal group; ^#P<0.05 and ^##P<0.01, vs. OGD/R group. OGD, oxygen-glucose deprivation; I, ischemia; R, reperfusion; PEDF, pigment epithelium derived factor; AQP, aquaporin; ECAR, extracellular acidification rate.