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. 2019 Mar 21;43(5):2153–2163. doi: 10.3892/ijmm.2019.4142

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Copyright: © Tyrtyshnaia et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Behavioral effects of AGE treatment on neuropathic pain. (A) The dynamics of cold allodynia: The moment of hind paw lifting above the cold plate (+4°C) for the 1-min observation. (B) Spontaneous locomotor activity in 'open field'. (C) Spatial working memory in the Y-maze. Data are the means ± SEM, n=7 per group, ^*P<0.05 and ^**P<0.01. (D) Long-term memory: Novel object recognition with the retention period of 24 h. Times of object exploration (left diagram); discrimination index, % (right diagram). Data are the means ± SEM, n=7 per group, ^*P<0.05, ^**P<0.01 and ^***P<0.001. AGE, alkyl glycerol ethers; Sham, sham-operated; CCI, chronic constriction injury.