Fig. 5.

Subretinal drusenoid deposits (SDD) and surrounding cells correlating to different appearances in multimodal imaging. IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; IS, inner segments; OS, outer segments; RPE, retinal pigment epithelium; ChC, choriocapillaris. ELM, green arrowheads; SDD, aqua arrowheads; Bruch membrane, black arrowheads. Retracted mitochondria in cone IS, dark green arrowheads. A. In the temporal area with target-like pseudodrusen (Figure 3, A and B), SDD (aqua arrowhead) are confluent and punctuated with OS crossing the deposit to reach RPE (yellow arrowheads), which is nonuniform in thickness. B. In areas with a roughened texture on NIR imaging (Figure 3B), SDD (aqua arrowhead) is less confluent with some caps resembling OS (yellow arrowhead), OS are shorter, and RPE is continuous but markedly dysmorphic with inward extensions (blue arrowhead). Basal linear deposit, red arrowheads. Basal mound, red arrow. Insets: top, sloughed⁷⁰ RPE cells. Bottom, phagocytes occasionally appearing among SDD in other sections. Detached retina in B was digitally reapproximated.