Figure 5.

No correlation in calf muscle or retinal CTSB to functional protection. (A) Active animals across all three exercise intensity groups were divided into high- and low-muscular CTSB levels. Animals with a calf muscle CTSB level 10% higher than the max inactive+LIRD animal were classified as “high CTSB” and compared with those below the threshold “low CTSB” for dark-adapted b-wave amplitude. The brightest flash dark-adapted b-wave amplitudes showed no correlation with calf muscle CTSB (B) and retinal CTSB protein (C). Circles represent measurements for individual animals. Data in A depicted as mean ± SEM. Linear regression line shown in B and C. Amp, amplitude.