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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Clin Cancer Res. 2018 Dec 18;25(7):2206–2218. doi: 10.1158/1078-0432.CCR-18-1368

Figure 1.

Figure 1.

Elevated expression of CXCR4 and MET correlates with poor prognosis and metastasis in uveal melanoma patients. A, Heatmap comparison of CXCR4, CXCL12 and MET, HGF mRNA expression in human uveal melanoma patients with or without metastasis (n = 46/group). B, Quantification of (A). C, Kaplan-Meier survival curves for UM patients (GSE22138) with high (n = 35) or low (n = 28) MET (Left) and CXCR4 (Right) mRNA levels. D, Representative immunofluorescence staining of CXCR4, c-Met and HIF-1α expression in ocular tumor tissue array from UM patients with or without metastasis. E, Quantification of percent positive tumor cells in (D). F, Survival time for metastatic patients and follow-up time for non-metastatic patients used for tissue array. **, p < 0.01; ***, p < 0.001;