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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Mol Cancer Res. 2018 Dec 26;17(4):974–986. doi: 10.1158/1541-7786.MCR-18-0504

Figure 1.

Figure 1.

STING-mediated dsDNA-induced innate immune activation is impaired in the majority of human ovarian cancer cell lines. A, Immunoblot of STING and cGAS in hTERT fibroblasts, normal human ovarian surface epithelial (HOSE) and a series of human ovarian cancer cell lines. cGAS expression was also analyzed by qPCR (bottom). B, ELISA analysis of human IFNβ production in the media of cells (same as in A) transfected with 3 μg/ml polyI:C or dsDNA90 or mock transfected for 16 hours. C, qPCR analysis of human IFNβ expression in cells (same as in A) transfected with 3 μg/ml polyI:C or dsDNA90 or mock transfected for 6 hours. D, qPCR analysis of human CXCL10 expression in cells (same as in C). Data are representative of at least two independent experiments. Error bars indicate SD. *p < 0.05, **p < 0.01, and ***p < 0.001; Student’s t test.