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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Clin Cancer Res. 2018 Dec 26;25(7):2314–2322. doi: 10.1158/1078-0432.CCR-18-2276

Figure 2. DCE-MRI detects responses to stroma-directed intervention (PEGPH20) in all three PDA models.

Figure 2.

Paired Ktrans values from orthotopic model (A) and (B) human xenograft before and after a single injection of PEGPH20 or VEH, as well as from KPC mice at baseline and post-three treatments of PEGPH20 plus gemcitabine (C). Percent changes of Ktrans and kep after the treatment from baseline (D-F). Baseline and post-treatment Ktrans map of the tumor (in color scale) overlaid on the respective T10 map (in grey scale, G-L). *: P< 0.05 compared to VEH group (Mann-Whitney U test).