Table 1.
AUCs of proteins with three or more hot spots higher in cases and their occurrence in the Ig bound and Ig free fractions by mass spectrometry
| Protein | Full Name | Hot spots per protein | Protein AUC | MS Ig Bound | MS Ig Free |
|---|---|---|---|---|---|
| CEP350 | centrosomal protein 350 | 3 | 0.7246 | Neg | Pos |
| SH3KBP1 | SH3 domain containing kinase binding protein 1 | 4 | 0.722 | Neg | Pos |
| EPS15 | epidermal growth factor receptor pathway substrate 15 | 3 | 0.7219 | Neg | Pos |
| ARHGAP33 | Rho GTPase activating protein 33 | 3 | 0.7216 | Pos | Pos |
| MKI67 | marker of proliferation Ki-67 | 4 | 0.7158 | Neg | Pos |
| AHNAK | AHNAK nucleoprotein | 5 | 0.7152 | Pos | Pos |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 3 | 0.7137 | Neg | Pos |
| MUC17 | mucin 17, cell surface associated | 3 | 0.713 | Pos | Neg |
| PCNXL3 | Pecanex-like protein 3 | 3 | 0.7097 | Neg | Pos |
| TPX2 | TPX2, microtubule nucleation factor | 3 | 0.6987 | Neg | Pos |
| FGD5 | FYVE, RhoGEF and PH domain containing 5 | 3 | 0.696 | Neg | Neg |
| EPPK1 | epiplakin 1 | 6 | 0.6954 | Neg | Pos |
| ZNF687 | zinc finger protein 687 | 3 | 0.6945 | Neg | Pos |
| TNXB | tenascin XB | 3 | 0.6942 | Pos | Pos |
| CAMSAP2 | calmodulin regulated spectrin associated protein family member 2 | 3 | 0.6936 | Pos | Neg |
| CTAG1A | cancer/testis antigen 1A | 3 | 0.6916 | Neg | Neg |
| KIFC1 | kinesin family member C1 | 3 | 0.6901 | Neg | Pos |
| SIPA1L3 | signal induced proliferation associated 1 like 3 | 4 | 0.6886 | Neg | Pos |
| FAM13A | family with sequence similarity 13 member A | 3 | 0.6883 | Neg | Neg |
| SOX4 | SRY-box 4 | 3 | 0.6867 | Pos | Pos |
| CTAG2 | cancer/testis antigen 2 | 3 | 0.6864 | Neg | Neg |
| KIF13B | kinesin family member 13B | 3 | 0.6864 | Pos | Neg |
| SMG1 | Serine/Threonine-Protein Kinase SMG1 | 4 | 0.6859 | Pos | Neg |
| BPTF | bromodomain PHD finger transcription factor | 4 | 0.6835 | Neg | Pos |
| ARFGEF3 | ARFGEF family member 3 | 4 | 0.6816 | Neg | Neg |
| SPTY2D1 | SPT2 chromatin protein domain containing 1 | 3 | 0.6814 | Neg | Pos |
| SNX18 | sorting nexin 18 | 3 | 0.6801 | Neg | Pos |
| ABCA13 | ATP binding cassette subfamily A member 13 | 3 | 0.6776 | Pos | Pos |
| GPATCH8 | G-patch domain containing 8 | 3 | 0.6748 | Pos | Pos |
| MED14 | mediator complex subunit 14 | 3 | 0.6742 | Pos | Neg |
| PLEKHH2 | pleckstrin homology, MyTH4 and FERM domain containing H2 | 3 | 0.6731 | Neg | Neg |
| EML3 | echinoderm microtubule associated protein like 3 | 3 | 0.6711 | Neg | Pos |
| MAPK8IP3 | mitogen-activated protein kinase 8 interacting protein 3 | 3 | 0.6691 | Neg | Pos |
| EIF5B | eukaryotic translation initiation factor 5B | 3 | 0.6672 | Neg | Neg |
| ALMS1 | ALMS1, centrosome and basal body associated protein | 3 | 0.6641 | Pos | Neg |
| GCC2 | GRIP and coiled-coil domain containing 2 | 3 | 0.662 | Pos | Neg |
| TIMELESS | timeless circadian regulator | 3 | 0.6615 | Pos | Pos |
| PDE4DIP | phosphodiesterase 4D interacting protein | 3 | 0.6612 | Neg | Pos |
| TNS1 | tensin 1 | 3 | 0.6529 | Pos | Neg |
| ATP1A4 | ATPase Na+/K+ transporting subunit alpha 4 | 3 | 0.6497 | Pos | Neg |
| RAD26L | DNA excision repair protein ERCC-6-like 2 | 3 | 0.6497 | Pos | Pos |
| COL12A1 | collagen type XII alpha 1 chain | 3 | 0.6493 | Pos | Pos |
| HRNR | hornerin | 5 | 0.6479 | Pos | Neg |
| DCHS2 | dachsous cadherin-related 2 | 3 | 0.6444 | Pos | Pos |
| CR1 | complement C3b/C4b receptor 1 (Knops blood group) | 5 | 0.6377 | Neg | Pos |
| PLCE1 | phospholipase C epsilon 1 | 3 | 0.636 | Neg | Neg |
| GOLGA6L4 | golgin A6 family-like 4 | 3 | 0.611 | Pos | Pos |
| FSCB | fibrous sheath CABYR binding protein | 6 | 0.6048 | Neg | Pos |