Pharmacological inhibition of Ezrin decreases PDAC self-renewal. A, Tumor colony formation and Annexin V surface expression of L3.6pl cells after 3 days of treatment with NSC305787. Error bars represent SD from 4 independent experiments. B, Sphere formation by low passage human xenografts following 3 days of NSC305787 treatment. Error bars represent SD from at least 4 independent experiments. *, 0.01<p<0.05; **, 0.001<p<0.01; ***, 0.0001<p<0.001