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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Clin Cancer Res. 2018 Nov 12;25(7):2228–2240. doi: 10.1158/1078-0432.CCR-18-0936

Figure 2. MMP14 expression correlates with ENG levels in ES cell lines and patients.

Figure 2.

(A-B) MMP14 presents a heterogeneous expression amongst ES cell lines, as determined by qRT-PCR (A). Relative protein expression of both ENG/MMP14 after normalization against GAPDH is depicted in (B). (C) Heterogeneous expression of ENG and MMP14 at the mRNA levels measured by qRT-PCR in a cohort of 22 frozen ES tumor samples. (D) Evaluation of ENG and MMP14 expression by IHC in 43 FFPE ES tumor samples (E). Significant correlation between ENG and MMP14 at the mRNA levels (r = 0.8331, p = 0.0001). (F) Representative images of different intensity scores (0, 2, 3) of ENG/MMP14 expression in ES patients.